- Complex Molecular Structure: a player needs to discard 6 City cards of the Virulent Strain color to cure the Virulent Strain; except for the Scientist, who needs to discard 5 cards, or the Field Operative, who must discard 4 cards and 3 cubes of the Virulent Strain color.
- Government Interference: it is not possible to remove a Virulent Strain cube without performing the Treat Disease action—for example, by using the Containment Specialist's ability, the Field Operative's ability, or a Remote Treatment or Rapid Vaccine Deployment event. However, it’s possible to do so using the Mobile Hospital event. Pawns affected by this effect cannot be moved by the Dispatcher, Airlift or Special Order, unless the current player first treats a Disease cube in the same city as the pawn.
- Rate Effect: if the Troubleshooter sees a Virulent Strain City card when looking at the Infection Deck while Rate Effect is active, the Troubleshooter does not look at an additional card.
